3,4,5-Trihydroxycinnamic acid decyl ester

Name	3,4,5-Trihydroxycinnamic acid decyl ester
Synonyms	3,4,5-Trihydroxycinnamic acid decyl ester 2-Propenoic acid, 3-(3,4,5-trihydroxyphenyl)-, decyl ester, (2E)-
CAS	1770778-45-4

Molecular Formula	C19H28O5
Molar Mass	336.42
Density	1.143±0.06 g/cm3(Predicted)
Boling Point	514.2±50.0 °C(Predicted)
pKa	8.82±0.15(Predicted)
Storage Condition	2-8°C，干燥，密封
In vitro study	3,4,5-Trihydroxycinnamic acid decyl ester (30 μM) exhibits an inhibitory potency of approximately 92% for pancreatic lipase in vitro. 3,4,5-Trihydroxycinnamic acid decyl ester (0.1-40 μM) inhibits pancreatic lipase activity in dose-dependent manner, with an EC 50 value being approximately 0.9 μM. 3,4,5-Trihydroxycinnamic acid decyl ester inhibits pancreatic lipase in vitro and lipid accumulation during 3T3-L1 cell differentiation.
In vivo study	3,4,5-Trihydroxycinnamic acid decyl ester (30-150 mg/kg; p.o.) suppresses a rise in blood triglyceride (TG) levels in mice given corn oil orally. Animal Model: 6 weeks old Male ddY mice Dosage: 30 mg/kg, 150 mg/kg Administration: Oral administration Result: Reduced plasma TG in a dose-dependent manner.

biological activity	3,4,5-Trihydroxycinnamic acid decyl ester is a highly effective lipid absorption and accumulation inhibitor with anti-obesity effect. The 3,4,5-Trihydroxycinnamic acid decyl ester is a pancreatic lipase (pancreatic lipase) inhibitor with an EC50 of approximately 0.9 μM.
target	EC50: 0.9 μM (pancreatic lipase)
in vitro study	3,4, 5-Trihydroxyamino acid decyl ester (30 μ m) exhibits an inhibitory potency of approximately 92% for pancreatic lipase in vitro.3, 4, 5-Trihydroxyamino acid decyl ester (0.1-40 μ m) inhibits pancreatic lipase activity in pose-dependent manner, with an EC 50 value being approximately 0.9 μM. 3,4, 5-Trihydroxyamino acid decyl ester inhibits pancreatic lipase in Vitro and Lipid accumulation during 3T3-L1 cell differentiation.
in vivo study	3,4, 5-Trihydroxyamino acid decyl ester (30-150 mg/kg; P. o.) suppresses a rise in blood triglyceride (TG) levels in mice given corn oilorally. Animal model: 6 weeks old male ddy mice dosage: 30 mg/kg, 150 mg/kg Administration: oral administration Result: Reduced plasma TG in a dose-dependent manner.
Animal Model:	6 weeks old Male ddY mice
Dosage:	30 mg/kg, 150 mg/kg
Administration:	Oral administration
Result:	Reduced plasma TG in a dose-dependent manner.

Last Update：2024-04-09 15:16:42

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